Changes in circulating filarial antigen status in previously positive individuals: Lessons for treatment monitoring and pre-transmission assessment surveys
In the present work, it has been shown that >90% of the previous CFA positive individuals seroreverted in 1 to 5 years post-baseline without additional MDA. The FTS is a more sensitive diagnostic tool that plausibly detects residual CFA in blood. The impact and influence of time as compared to additional ivermectin/Albendazole intake, on CFA seroreversion in this study was significant (p < 0.001).
Authors
- Linda Batsa Debrah (ORCID: https://orcid.org/0000-0001-9620-3408)
- Charles Gyasi (ORCID: https://orcid.org/0000-0002-7549-7117)
- John Boateng (ORCID: https://orcid.org/0000-0003-1309-2840)
- John Kwaku Opoku (ORCID: https://orcid.org/0000-0001-7534-8843)
- Ute Klarmann‐Schulz (ORCID: https://orcid.org/0000-0001-5826-0196)
- Alexander Yaw Debrah (ORCID: https://orcid.org/0000-0001-5721-0891)
- Derrick Adu Mensah
- Inge Kroidl (ORCID: https://orcid.org/0000-0002-6949-346X)
- Achim Hoerauf (ORCID: https://orcid.org/0000-0002-8671-3831)
- Prince Obeng (ORCID: https://orcid.org/0000-0003-4653-633X)
- Vera Serwaa Opoku (ORCID: https://orcid.org/0000-0001-7950-6650)
- Jubin Osei-Mensah (ORCID: https://orcid.org/0000-0003-3470-2994)
- Monica Ahiadorme
- Emmanuel Donawobuge Kutu
- Prince Dennis Atisu (ORCID: https://orcid.org/0009-0000-8726-1585)
Institutions
- University Hospital Bonn (DE)
- Kwame Nkrumah University of Science and Technology (GH)
- LMU Klinikum (DE)
- German Center for Infection Research (DE)
- Kumasi Centre for Collaborative Research in Tropical Medicine (GH)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1371/journal.pntd.0012802
- Citations
- 3
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Deutsches Zentrum für integrative Biodiversitätsforschung Halle-Jena-Leipzig