SGLT2i Therapy Prevents Anthracycline-Induced Cardiotoxicity in a Large Animal Model by Preserving Myocardial Energetics
Sodium-glucose cotransporter-2 inhibitor therapy with empagliflozin exerts a dose-dependent cardioprotective effect against AIC. The improved LVEF was accompanied by enhanced ketone body consumption, improved cardiac energetics, and preserved mitochondrial structure and function.
Authors
- Carlos Galán‐Arriola (ORCID: https://orcid.org/0000-0001-7403-8974)
- Borja Ibáñez (ORCID: https://orcid.org/0000-0002-5036-254X)
- Annalaura Mastrangelo (ORCID: https://orcid.org/0000-0003-2650-0444)
- Antonio Molina (ORCID: https://orcid.org/0000-0002-5603-8492)
- Danielle Medina-Hernández
- Gonzalo J. López-Martín
- David Sancho (ORCID: https://orcid.org/0000-0003-2890-3984)
- M I Higuero-Verdejo
- Warren Skoza
- Javier Sánchez‐Gonzalez (ORCID: https://orcid.org/0000-0003-1427-3870)
- Valentı́n Fuster (ORCID: https://orcid.org/0000-0002-9043-9986)
- Claudia Pérez‐Martínez (ORCID: https://orcid.org/0000-0001-8060-6368)
- Laura Cádiz (ORCID: https://orcid.org/0000-0001-9212-7970)
- Andrea Moreno‐Arciniegas
- Miguel Fernández Tocino
- María Caballero-Valderrama
- Alejandro Treviño Becerra
- Antonia Priego
Institutions
- Mount Sinai Hospital (US)
- Instituto de Salud Carlos III (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Centro de Investigación Biomédica en Red (ES)
- Philips (Spain) (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Universidad de León (ES)
Publication Details
- Journal
- JACC CardioOncology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.jaccao.2024.12.004
- Citations
- 16
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 22.21
Funders
- “la Caixa” Foundation
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Centro Nacional de Investigaciones Cardiovasculares
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación