Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival
This study reveals that S. aureus enhances IL10 production by inhibiting HDAC11, thereby promoting mitophagy and mtROS clearance, which supports its survival within macrophages. These findings offer new insights into the intracellular survival mechanisms of S. aureus and provide potential therapeutic approaches for the clinical management of osteomyelitis.
Authors
- Ning Hu (ORCID: https://orcid.org/0000-0001-9933-5924)
- Yidong Shen (ORCID: https://orcid.org/0000-0002-2841-7233)
- Wei Huang (ORCID: https://orcid.org/0000-0002-8894-0982)
- Quanming Zou
- Hao Zeng (ORCID: https://orcid.org/0000-0002-1831-3019)
- Leilei Qin (ORCID: https://orcid.org/0000-0002-9443-7080)
- Yanhao Zhang (ORCID: https://orcid.org/0000-0002-2740-0499)
- Haotian Zhou (ORCID: https://orcid.org/0009-0008-7598-010X)
- Yaji Yang
- Feilong Li (ORCID: https://orcid.org/0009-0002-4430-4324)
- Jianye Yang (ORCID: https://orcid.org/0000-0001-5172-1068)
Institutions
- Army Medical University (CN)
- Nantong University (CN)
- Yancheng First People's Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Emergency Medical Center (CN)
- Chongqing Dazu District People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12967-025-06161-7
- Citations
- 10
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 13.54
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment