Efficient synthesis of Azabicyclo[3.1.1]heptanes via Strain-release Cycloadditions of Bicyclo[1.1.0]butanes
Azabicyclo[3.1.1]heptanes are recognized as bioisosteres of the meta-substituted pyridine scaffold, as their bridgehead substitution mimics the arrangement of substituents on the meta-substituted pyridine. However, the synthesis of azabicyclo[3.1.1]heptanes remains underdeveloped. This mini-review highlights recent advances in their synthesis through strain-release cycloadditions of bicyclo[1.1.0]butanes.
Authors
- Takuma Tagami (ORCID: https://orcid.org/0000-0001-9511-1499)
Institutions
- Kyushu University (JP)
Publication Details
- Journal
- Journal of Synthetic Organic Chemistry Japan
- Published
- 2025-02-01
- DOI
- https://doi.org/10.5059/yukigoseikyokaishi.83.153
- Citations
- 1
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.94