PLACE: Multicenter Study for Right Ventricular Failure on Mechanical Cardiocirculatory Supports

Isolated acute right ventricular failure (aRVF) is associated with poor prognosis in different scenarios. In severe conditions, temporary mechanical cardiocirculatory support (tMCS) is required. PLACE is an international, retrospective, multicenter registry including 17 centers that investigated patients affected by isolated aRVF and treated with various types of tMCS from January 2000 to December 2020. The registry included 644 (69.6% males, mean age: 55 years) patients. The most frequent etiologies were post-left ventricular assist device implantation (LVAD) and postcardiotomy shock. These patients received mostly mechanical circulatory support (MCS) and veno-arterial extracorporeal membrane oxygenation. Mean tMCS duration was 9 days, weaning was achieved in 70.5% of the patients, and the major cause of death on support was multiorgan failure (50.5%). The mortality rate was 45 and 48.4% in-hospital and at 3 month follow-up, respectively. Multivariable logistic regression analysis identified age, aRVF due to acute pulmonary hypertension, bilirubin level, and oliguria or anuria at tMCS implantation as risk factors for in-hospital mortality. Conversely, aRVF after LVAD was found to be associated with a lower risk of early mortality. In-hospital and 3 months mortality occurred in less than half of the aRVF-supported subjects. Furthermore, several preimplant aspects such as age, organ function, and type of tMCS are independently associated with in-hospital and 3 month mortality.

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Publication Details

Journal
ASAIO Journal
Published
2025-02-04
DOI
https://doi.org/10.1097/mat.0000000000002328
Citations
5
Primary Topic
Mechanical Circulatory Support Devices
Type
article
Field-Weighted Citation Impact
3.37
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article

PLACE: Multicenter Study for Right Ventricular Failure on Mechanical Cardiocirculatory Supports

Yih‐Sharng Chen, Michele Di Mauro, Tom Verbelen, Dominik Wiedemann et al.
5 citations
ASAIO Journal
Mechanical Circulatory Support Devices
3.37
article

PLACE: Multicenter Study for Right Ventricular Failure on Mechanical Cardiocirculatory Supports

Yih‐Sharng Chen, Michele Di Mauro, Tom Verbelen, Dominik Wiedemann, Kasia Hryniewicz, Antonio Loforte, Roberto Lorusso, Federico Pappalardo, Lo Coco, Lars Mikael Broman, Thomas Fux, Udo Boeken, Dominik J. Vogel, Paolo Masiello, Jamila Kremer, Koji Takeda, Andrea Ballotta, Jacinta J. Maas, Matteo Pozzi
article en
5 citations

Abstract

Isolated acute right ventricular failure (aRVF) is associated with poor prognosis in different scenarios. In severe conditions, temporary mechanical cardiocirculatory support (tMCS) is required. PLACE is an international, retrospective, multicenter registry including 17 centers that investigated patients affected by isolated aRVF and treated with various types of tMCS from January 2000 to December 2020. The registry included 644 (69.6% males, mean age: 55 years) patients. The most frequent etiologies were post-left ventricular assist device implantation (LVAD) and postcardiotomy shock. These patients received mostly mechanical circulatory support (MCS) and veno-arterial extracorporeal membrane oxygenation. Mean tMCS duration was 9 days, weaning was achieved in 70.5% of the patients, and the major cause of death on support was multiorgan failure (50.5%). The mortality rate was 45 and 48.4% in-hospital and at 3 month follow-up, respectively. Multivariable logistic regression analysis identified age, aRVF due to acute pulmonary hypertension, bilirubin level, and oliguria or anuria at tMCS implantation as risk factors for in-hospital mortality. Conversely, aRVF after LVAD was found to be associated with a lower risk of early mortality. In-hospital and 3 months mortality occurred in less than half of the aRVF-supported subjects. Furthermore, several preimplant aspects such as age, organ function, and type of tMCS are independently associated with in-hospital and 3 month mortality.

ASAIO JournalVol. 71(4)
National Health Service (GB), Libera Università Maria SS. Assunta (IT), Apple (Israel) (IL), Karolinska University Hospital (SE), Heidelberg University (DE), Columbia University Irving Medical Center (US), Leiden University Medical Center (NL), Maastricht University Medical Centre (NL), University Hospital Heidelberg (DE), Karolinska Institutet (SE), Ider University (MN), Maastricht University (NL), Düsseldorf University Hospital (DE), Centro Cardiologico Monzino (IT), National Taiwan University Hospital (TW), Minneapolis Heart Institute Foundation (US), Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT), Hôpital Louis Pradel (FR), Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT), Heinrich Heine University Düsseldorf (DE), University of Turin (IT), Medical University of Vienna (AT), KU Leuven (BE)
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Openalex Percentile: Top 9%
Mechanical Circulatory Support Devices
3.37
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