Wnt signaling as a translational target in rheumatoid and psoriatic arthritis
This study compares the involvement of Wnt signaling in RA and PsA, suggesting that Wnt signaling may represent a possible mechanism of disease activity. In particular, it indicates that DKK1 levels are correlated with CTX-1, a marker of bone resorption, and with disease activity in RA patients. These findings underscore the importance of these biomarkers in the potential monitoring of patients, offering insights into disease mechanisms and potential therapeutic targets.
Authors
- Cristiano Alessandri (ORCID: https://orcid.org/0000-0003-4149-5321)
- Gloria Riitano
- Antonella Capozzi (ORCID: https://orcid.org/0000-0001-6508-7731)
- Maurizio Sorice (ORCID: https://orcid.org/0000-0003-3534-1502)
- Daniela Caissutti (ORCID: https://orcid.org/0000-0002-5054-8061)
- Fabrizio Conti (ORCID: https://orcid.org/0000-0002-1897-049X)
- Roberta Misasi (ORCID: https://orcid.org/0000-0002-1181-6190)
- Cristina Garufi (ORCID: https://orcid.org/0000-0002-9065-4440)
- Valeria Manganelli (ORCID: https://orcid.org/0000-0001-8517-4533)
- Tina Garofalo (ORCID: https://orcid.org/0000-0003-0645-2510)
- Francesca Romana Spinelli (ORCID: https://orcid.org/0000-0003-1969-2097)
- Agostina Longo (ORCID: https://orcid.org/0000-0002-1384-4232)
Institutions
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12967-025-06174-2
- Citations
- 20
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 33.36