Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
The neutrophil elastase PET-tracer [<sup>11</sup>C]NES is a novel and unique instrument to study the acute innate neutrophil immune response in sepsis and associated vital organ failure. We here present images and quantitative data of the neutrophil elastase distribution the first hours of acute experimental sepsis. Surprisingly, a pronounced increase of neutrophil elastase was found in the bone marrow 2 h into the sepsis reaction followed at 4 h by increase in the liver, spleen and lungs and a concomitant reduction of the tracer uptake in bone marrow.
Authors
- Helena Janols (ORCID: https://orcid.org/0000-0002-3857-163X)
- Markus Castegren (ORCID: https://orcid.org/0000-0002-9292-0298)
- Amina Khalil (ORCID: https://orcid.org/0009-0007-8567-2277)
- Sara M. Mangsbo (ORCID: https://orcid.org/0000-0002-1355-2678)
- Olof Eriksson (ORCID: https://orcid.org/0000-0002-2515-8790)
- Rose‐Marie Amini (ORCID: https://orcid.org/0000-0003-0901-5252)
- Miklós Lipcsey (ORCID: https://orcid.org/0000-0002-1976-4129)
- Paul Skorup (ORCID: https://orcid.org/0000-0002-5407-6612)
- Gunnar Antoni (ORCID: https://orcid.org/0000-0002-1525-5255)
- Jonathan Sigfridsson (ORCID: https://orcid.org/0000-0001-8382-3624)
- Sergio Estrada (ORCID: https://orcid.org/0000-0002-8388-4619)
- Anders Olof Larsson (ORCID: https://orcid.org/0000-0003-3161-0402)
- Frida Wilske (ORCID: https://orcid.org/0000-0002-2633-4063)
- Anders Wall
- Viola Wilson
- Jan Sjölin
Institutions
- Uppsala University (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s40635-025-00721-3
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Uppsala Universitet