Development of an automated method for in-house production of sodium 18F-fluoride for injection: process validation as a step toward routine clinical application
A new simple and reliable procedure developed for the preparation and dispensing of injectable [<sup>18</sup>F]NaF in less than 10 min with a radiochemical yield > 97% (decay corrected) has been successfully developed. Notably, the proposed method also allows the preparation of [<sup>18</sup>F]NaF using the residual fluorine-18 activity remaining after a [<sup>18</sup>F]FDG production run, thus making it immediately accessible to patients for further PET imaging investigations.
Authors
- Maja Velickovska
- Paulina Apostolova (ORCID: https://orcid.org/0000-0002-3059-2006)
- Emilija Janevik-Ivanovska (ORCID: https://orcid.org/0000-0002-8493-5481)
- Ana Ugrinska (ORCID: https://orcid.org/0000-0001-6558-3890)
- Filip Jolevski (ORCID: https://orcid.org/0000-0003-0716-9418)
- Marija Atanasova Lazareva (ORCID: https://orcid.org/0000-0002-1516-8303)
- Maja Chochevska (ORCID: https://orcid.org/0000-0002-8720-342X)
- Katerina Kolevska (ORCID: https://orcid.org/0000-0002-8312-218X)
Institutions
- Institute of public health of Republic of Macedonia (MK)
- Goce Delcev University (MK)
- Ss. Cyril and Methodius University in Skopje (MK)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s41181-025-00329-8
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00