Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway
In conclusion, our findings suggest that asiaticoside exerts its antidepressant-like effects through the modulation of BDNF/Nrf2/GPX4 signaling pathway against neuronal ferroptosis in the hippocampal CA1 region.
Authors
- Guang‐Hui Xu (ORCID: https://orcid.org/0000-0002-4537-8803)
- Chaojun Fan (ORCID: https://orcid.org/0000-0003-4578-0760)
- An Zhou (ORCID: https://orcid.org/0000-0001-8338-5580)
- Li‐Tao Yi (ORCID: https://orcid.org/0000-0001-9052-8607)
- Wei-Feng Huang (ORCID: https://orcid.org/0000-0002-9755-7299)
- Cheng‐Fu Li (ORCID: https://orcid.org/0000-0002-5119-6969)
- Hong Feng (ORCID: https://orcid.org/0000-0002-2884-4905)
- Jun Wang (ORCID: https://orcid.org/0000-0003-2509-9599)
- Zhong-Yu Yuan (ORCID: https://orcid.org/0009-0004-5259-9817)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Huaqiao University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Hua Medicine (China) (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dddt.s509208
- Citations
- 11
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 9.26