Plasma-derived exosomal miR-144-3p targeting IL-1β is involved in pressure pain threshold regulation at PC6 acupoint in myocardial ischemia rats
PPT decreased and MCD increased at PC6 in MI rats and miR-144-3p is a key molecule in the induction of these phenomenon. Furthermore, miR-144-3p targeting Interleukin-1β (IL-1β) leads to local MCD, neurogenic inflammation and peripheral nociceptor hypersensitization, finally resulting in PPT change at PC6. Innovatively, our study also provides a new direction for investigating the relationship between MCs, PPT and sensitivity of acupoints, which is mediated by miR-144-3p.
Authors
- Wenchuan Qi (ORCID: https://orcid.org/0000-0002-3294-8870)
- Yanrong Ren (ORCID: https://orcid.org/0000-0002-3597-1945)
- Xiang Li
- Yuxin Sun
- Qianhua Zheng (ORCID: https://orcid.org/0000-0001-5489-7034)
- Xiao Li
- Yu Liu (ORCID: https://orcid.org/0000-0001-7111-6391)
- Ziwen Wang (ORCID: https://orcid.org/0000-0002-3724-1620)
- Fanrong Liang (ORCID: https://orcid.org/0000-0001-8518-9268)
- F Ling
Institutions
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Traditional and Complementary Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1016/j.jtcme.2025.02.001
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00