Urinary Dickkopf-related protein 3 as a novel biomarker for kidney function decline in children with Alport syndrome
Urinary DKK3 is significantly elevated in children at early stages of AS. There was a potential association between higher DKK3 levels, worsening albuminuria, and a decline in kidney function. These findings suggest that DKK3 may be a prognostic marker for predicting the risk of kidney damage in children with AS.
Authors
- Matthias Galiano
- Angelika Hafke
- Lutz T. Weber (ORCID: https://orcid.org/0000-0003-4116-598X)
- Sabine König
- Dennis Pieper
- Baerbel Lange‐Sperandio
- Oliver Groß (ORCID: https://orcid.org/0000-0002-8390-8852)
- Manuel Wallbach (ORCID: https://orcid.org/0000-0002-1162-4682)
- Max C. Liebau (ORCID: https://orcid.org/0000-0003-0494-9080)
- Dieter Haffner (ORCID: https://orcid.org/0000-0002-9601-7813)
- Shekib A. Jami (ORCID: https://orcid.org/0000-0001-5478-1963)
- Stefan Kohl (ORCID: https://orcid.org/0000-0001-9600-8231)
- Matthias Kettwig (ORCID: https://orcid.org/0000-0003-4804-7716)
- Lars Pape (ORCID: https://orcid.org/0000-0002-3635-6418)
- Ulrike John-Kroegel
- Jens König (ORCID: https://orcid.org/0000-0002-9732-8656)
- Jan Boeckhaus (ORCID: https://orcid.org/0009-0006-2021-9255)
- Kay Latta
- Gry H. Dihazi (ORCID: https://orcid.org/0000-0002-3214-7969)
- Jutta Gellermann
- Burkhard Tönshoff
- Henry Fehrenbach
Institutions
- University of Cologne (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Medizinische Hochschule Hannover (DE)
- University Hospital Münster (DE)
- Universitätsmedizin Göttingen (DE)
- German Centre for Cardiovascular Research (DE)
- Jena University Hospital (DE)
- University Hospital Cologne (DE)
- University of Duisburg-Essen (DE)
- University of Göttingen (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Pediatric Nephrology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1007/s00467-025-06696-3
- Citations
- 4
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Bundesministerium für Bildung und Forschung