Insight into the Axial Chirality in Benzodiazepines
1,4-Benzodiazepines, which are important core structures found in hypnotic and anxiolytic drugs, exhibit latent axial chirality. This article describes this axial chirality based on the sp2-sp2 axis arising from the Ar-NC(＝O) axis (axis 1) and the Ar-C(＝N) axis (axis 2). The dynamic axial chirality of this scaffold is considered a key core structure contributing to biological activity.
Authors
- Hideaki Natsugari (ORCID: https://orcid.org/0000-0002-6442-1598)
- Ryoko Tanaka
- Hideyo Takahashi (ORCID: https://orcid.org/0000-0001-5965-3987)
- Ryota Takano
Institutions
- Tokyo University of Science (JP)
Publication Details
- Journal
- Journal of Synthetic Organic Chemistry Japan
- Published
- 2025-02-01
- DOI
- https://doi.org/10.5059/yukigoseikyokaishi.83.119
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00