Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway
The findings showed that TTT enhanced the production of growth factors that in turn activated EPC proliferation and migration through the Ras/Raf/MEK/ERK pathway, ultimately contributing to angiogenesis and DFU healing. Based on these findings, we proposed a theory that remote continuous microinjuries can trigger the repair of target tissues (ie, microinjury-induced remote repair, MIRR). Future studies are needed to validate this theory.
Authors
- William W. Lu (ORCID: https://orcid.org/0000-0002-5780-2886)
- Xiaomei Wu (ORCID: https://orcid.org/0000-0002-1075-1823)
- Can Yang (ORCID: https://orcid.org/0000-0002-4407-3055)
- Rongyuan Liang
- Zeying Fan (ORCID: https://orcid.org/0000-0001-9700-1867)
- Yeping Chen (ORCID: https://orcid.org/0009-0002-8499-3734)
- Qikai Hua (ORCID: https://orcid.org/0000-0001-5101-6115)
- Yan Chen
- Jie Liu (ORCID: https://orcid.org/0000-0002-5264-4612)
- Xiping Luo (ORCID: https://orcid.org/0000-0001-9802-1536)
- Yanfang Yang (ORCID: https://orcid.org/0000-0001-7317-5651)
- Xinyun Liang
- Yangzhou Mo
- Xiajie Huang
Institutions
- Guangxi Medical University (CN)
- Chinese University of Hong Kong (HK)
- First Affiliated Hospital of GuangXi Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s493505
- Citations
- 4
- Primary Topic
- Diabetic Foot Ulcer Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.18