LiClO4/EG as an Environmentally Benign Lewis Acidic Catalytic System for the Expeditious Synthesis of 2,3-Dihydroquinazolin-4 (1H)-ones and NH-1,2,3-Triazoles
Abstract An environmentally benign protocol has been developed for the synthesis of two biologically important N-heterocycles; namely, 2,3-dihydroquinazolin-4(1H)-ones and NH-1,2,3-triazoles. These two N-heterocyclic systems are synthesized using readily available and inexpensive LiClO4 in ethylene glycol (EG) and PEG-400 with good to excellent product yield. The method provides an important benchmark for the rapid, operationally simple synthesis of these two heterocycles. Sc-XRD analysis of one of the products gives structural information and DFT calculations provide important information on the mechanistic pathway.
Authors
- Pranjit Kumar Bora (ORCID: https://orcid.org/0000-0002-8729-7040)
- Manashjyoti Konwar
- Farnaz Yashmin (ORCID: https://orcid.org/0000-0001-8956-3296)
- Swadhin Chetia (ORCID: https://orcid.org/0000-0002-1355-9271)
- Ankur K. Guha (ORCID: https://orcid.org/0000-0003-4370-8108)
- Apurba Dutta (ORCID: https://orcid.org/0000-0002-5677-7252)
- Babulal Das (ORCID: https://orcid.org/0000-0003-4160-601X)
- Dimanta Sho
Institutions
- Indian Institute of Technology Guwahati (IN)
- Central Institute of Indian Languages (IN)
- The Sanskrit College and University (IN)
- Cotton University (IN)
- Dibrugarh University (IN)
- Indian Institute of Technology Indore (IN)
Publication Details
- Journal
- Synlett
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1055/a-2532-7424
- Citations
- 1
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.94