Advances in the 1,2-Metalate Rearrangement Chemistry of Alkenylboronates

Abstract Synthetic methods that involve the formation of multiple bonds in a one-pot fashion have played a crucial role in organic chemistry. However, many features of these approaches are still limited, such as stereocontrol and chemoselectivity, especially when nonadjacent stereocenters are formed. Herein, we outlined our efforts in addressing these challenges by advancing the 1,2-metalate shift of alkenylboronic esters. 1 Introduction 2 1,2-Migration Strategy on Nitrogen-Containing Heterocyclic Substrates 3 Enantioselective Allylation with Metal(π-Allyl) Intermediates 4 Conclusion