Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus
In summary, the current study identified NMM as a broad-spectrum potent antibacterial agent and elucidated its plausible mechanism of action primarily by targeting G4-motif in the mraZ promoter of the dcw gene cluster.
Authors
- Wanki Yoo (ORCID: https://orcid.org/0000-0003-3619-9720)
- Shrute Kannappan (ORCID: https://orcid.org/0000-0001-9565-0564)
- Hye-Ra Lee (ORCID: https://orcid.org/0000-0003-3815-3291)
- Truc Kim (ORCID: https://orcid.org/0000-0003-1650-4169)
- Maria Razzaq (ORCID: https://orcid.org/0000-0002-5189-2278)
- Vinod Kumar Subramani (ORCID: https://orcid.org/0000-0001-9288-7064)
- Akhilesh Kumar Chaurasia (ORCID: https://orcid.org/0000-0001-6077-126X)
- Kyeong Kyu Kim (ORCID: https://orcid.org/0000-0003-2515-8894)
- Shreyasi Das (ORCID: https://orcid.org/0009-0002-4011-5112)
- Joohyun Lee (ORCID: https://orcid.org/0000-0003-1696-8991)
- Maria Sultan
Institutions
- Korea University (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s12929-024-01109-3
- Citations
- 4
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 6.87
Funders
- National Research Foundation of Korea