A multiplex assay of leptin, resistin, and adiponectin by immunoaffinity enrichment and targeted mass spectrometry
A multi-IA-LC-MS/MS assay was developed for the simultaneous and sensitive measurement of leptin, resistin, and adiponectin in clinical samples. This quantitative method shows significant potential for applications related to obesity and could facilitate improved clinical management and understanding of obesity-related conditions.
Authors
- Xinxin Yang (ORCID: https://orcid.org/0000-0002-2024-4307)
- Shane S. Kelly (ORCID: https://orcid.org/0000-0002-6252-5895)
- Thomas Fillmore (ORCID: https://orcid.org/0000-0002-3763-589X)
- Jun Qu (ORCID: https://orcid.org/0000-0002-1346-6809)
- Jie Pu
- Bret H. Goodpaster (ORCID: https://orcid.org/0000-0003-1275-5147)
- Marina Gritsenko (ORCID: https://orcid.org/0000-0001-9992-9829)
- Tujin Shi (ORCID: https://orcid.org/0000-0002-5592-3588)
- Weijun Qian (ORCID: https://orcid.org/0000-0002-5393-2827)
- Adam Swensen (ORCID: https://orcid.org/0000-0001-8135-1766)
- James P. DeLany (ORCID: https://orcid.org/0000-0003-0366-3849)
- Stephen R. Master (ORCID: https://orcid.org/0000-0002-6808-631X)
- Tai‐Tu Lin (ORCID: https://orcid.org/0000-0002-8985-0364)
Institutions
- Children's Hospital of Philadelphia (US)
- Pacific Northwest National Laboratory (US)
- Translational Research Institute for Metabolism and Diabetes (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Journal of Mass Spectrometry and Advances in the Clinical Lab
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1016/j.jmsacl.2025.01.003
- Citations
- 1
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- U.S. Department of Energy
- University of Washington
- Cedars-Sinai Medical Center
- University at Buffalo
- National Institute of Diabetes and Digestive and Kidney Diseases
- Pacific Northwest National Laboratory