Association between antidepressant drugs and falls in older adults: A mediation analysis in the World Health Organization's pharmacovigilance database
In multivariate disproportionality analyses, all antidepressant drugs classes were associated with signals of disproportionate reporting of falls in older adults, except for NSMRIs. In mediation analyses, a direct effect on the falls reports was only found for alpha-2-adrenergic receptor antagonists. Single-mediators based models seem insufficient to explain the diversity of clinical settings resulting in falls. These findings underline the necessity of a comprehensive analysis of all clinical and pharmacological features in older falling adults treated with antidepressant drugs.
Authors
- Basile Chrétien (ORCID: https://orcid.org/0000-0002-7483-2489)
- Marie Heraudeau
- Thierry Lobbedez (ORCID: https://orcid.org/0000-0002-0945-8056)
- Soumia Benbrika
- Clémence Bechade (ORCID: https://orcid.org/0000-0002-8481-6589)
- Cédric Villain (ORCID: https://orcid.org/0000-0002-2050-2767)
- Elise-Marie Minoc
- Charles Dolladille (ORCID: https://orcid.org/0000-0003-0449-6261)
- Véronique Lelong‐Boulouard (ORCID: https://orcid.org/0000-0002-7876-7266)
- Claire Lafont
Institutions
- Inserm (FR)
- Normandie Université (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Therapies
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1016/j.therap.2025.01.004
- Citations
- 1
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 3.13