Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus
In summary, elevated serum level of IFN-α was responsible for increased secretion of granzyme B and enhanced cytotoxicity of CD8<sup>+</sup>T cells in SLE and this process may be related to PI3K pathway. Relevant molecules and mechanism remains to be explored in the future.
Authors
- Jia-yuan Wang
- Chenxing Zhang (ORCID: https://orcid.org/0000-0002-3727-7906)
- Ying Wang (ORCID: https://orcid.org/0000-0003-1787-0515)
- Yehui Tan (ORCID: https://orcid.org/0000-0002-6378-2156)
- Shujun Wang (ORCID: https://orcid.org/0000-0002-3740-7870)
- Lei Yin (ORCID: https://orcid.org/0000-0003-4795-8710)
- Meiyu Zhang (ORCID: https://orcid.org/0000-0003-1256-3575)
- Kang Shao (ORCID: https://orcid.org/0009-0000-0655-5371)
- Ping Ji (ORCID: https://orcid.org/0000-0002-3027-6142)
- You-ying Mao
Institutions
- Hunan Normal University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Children's Medical Center (CN)
- Songjiang District Central Hospital (CN)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100276
- Citations
- 3
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- National Natural Science Foundation of China