Trends and Outcomes of Readmissions Following Post-Procedural Stroke in Patients Undergoing Transcatheter Edge-to-Edge Repair: Insights From the National Readmission Database (2016-2020)

Introduction Transcatheter edge-to-edge repair (TEER) procedure for the repair of significant symptomatic mitral regurgitation has become increasingly popular in recent years. Stroke is a well-known complication of many surgical procedures. However, the association of stroke on outcomes of TEER in patients has not been adequately reported in the literature. Methods We queried the National Readmission Database from 2016 to 2020 using ICD-10 codes to identify the patients admitted for TEER. The patients were divided into two groups: patients with stroke and patients without stroke. Outcomes were assessed between two cohorts at index admissions and readmissions due to stroke. Results A total of 16,719 patients were admitted for TEER procedure, and 97 patients were diagnosed with new onset acute stroke/cerebrovascular accident (CVA). The most common comorbidities in the study population admitted with acute CVA were hypertension, hyperlipidemia, history of nicotine use, and coronary artery disease. On multivariate regression analysis, patients admitted with acute CVA compared to the patients without acute CVA had significantly higher odds of in-hospital mortality, acute kidney injury, post-procedural bleeding, acute myocardial infarction, and mechanical circulatory support. Conclusion Patients in the acute CVA group had higher rates of readmissions, mean length of stay in the hospital, and higher healthcare burden.