Combined Analyses of Circulating Tumor DNA and Immunoscore in Patients With Stage III Colon Cancer: A Post Hoc Analysis of the PRODIGE-GERCOR IDEA-France/HORG-IDEA-Greece Trials
In this combined analysis of two adjuvant trials dedicated to patients with stage III CC after surgery, ctDNA was detectable in 19.7% of the patients and was confirmed as a major independent prognostic biomarker. IS seems to bring additional prognostic information in the 80.3% of patients who are ctDNA-negative.
Authors
- Christophe Louvet (ORCID: https://orcid.org/0000-0002-2240-4706)
- Ioannis Boukovinas (ORCID: https://orcid.org/0000-0003-4475-1802)
- Konstantinos Vogiatzoglou
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Minetta C. Liu (ORCID: https://orcid.org/0000-0002-8206-5232)
- Jaafar Bennouna (ORCID: https://orcid.org/0000-0002-5034-1108)
- Thibault Mazard (ORCID: https://orcid.org/0000-0002-5644-9603)
- Pascal Artru (ORCID: https://orcid.org/0000-0002-9777-0866)
- Himanshu Sethi (ORCID: https://orcid.org/0000-0002-5787-8901)
- Céline Lepère (ORCID: https://orcid.org/0000-0001-5101-6000)
- Jean‐François Emile (ORCID: https://orcid.org/0000-0002-6073-4466)
- Jérôme Galon (ORCID: https://orcid.org/0000-0001-9635-1339)
- Olivier Bouché (ORCID: https://orcid.org/0000-0002-8284-3743)
- John Souglakos (ORCID: https://orcid.org/0000-0002-1642-1147)
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- Ippokratis Messaritakis (ORCID: https://orcid.org/0000-0003-1877-500X)
- Franck Pagès (ORCID: https://orcid.org/0000-0002-2083-610X)
- Maria Tzardi
- Pierre Laurent‐Puig (ORCID: https://orcid.org/0000-0001-8475-5459)
- Shruti Sharma (ORCID: https://orcid.org/0000-0003-0290-1569)
- Déwi Vernerey (ORCID: https://orcid.org/0000-0001-6399-926X)
- Antoine Falcoz
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Crete (GR)
- Inserm (FR)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Institute Mutualiste Montsouris (FR)
- Centre de Recherche des Cordeliers (FR)
- Methodology and Quality of Life Unit in Oncology (FR)
- La Ligue Contre le Cancer (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Saint-Antoine (FR)
- Natera (United States) (US)
- Hôpital Robert-Debré (FR)
- Hôpital Privé Jean Mermo (FR)
- Établissement Français du Sang (FR)
- Laboratoire d’immunologie intégrative du cancer (FR)
- University Hospital of Heraklion (GR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Hôpital Foch (FR)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1200/jco.24.00648
- Citations
- 15
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 14.04
Funders
- Sanofi
- Veracyte
- Natera
- Fondation ARC pour la Recherche sur le Cancer
- Institut National Du Cancer