Baseline Liquid Biopsy in Relation to Tissue-Based Parameters in Metastatic Colorectal Cancer: Results From the Randomized FIRE-4 (AIO-KRK-0114) Study
LB allows the detection of <i>RAS</i> and <i>BRAF</i> mutations in patients deemed <i>RAS</i>wt on the basis of tissue analyses. These patients show outcome characteristics expected for <i>RAS</i>- and <i>BRAF</i>-mutant patients in tissue. The study thus confirms the high clinical relevance of LB performed at baseline before the start of therapy.
Authors
- Martin Fuchs (ORCID: https://orcid.org/0000-0003-4824-2511)
- Matthias Sandmann
- Birgit Gruenberger
- Alexander Baraniskin (ORCID: https://orcid.org/0000-0002-0408-1552)
- Andreas Dickhut
- Sebastian Stintzing (ORCID: https://orcid.org/0000-0002-3297-5801)
- Volker Heinemann (ORCID: https://orcid.org/0000-0002-1349-3321)
- Thomas Decker (ORCID: https://orcid.org/0000-0003-3814-8775)
- Gerald W. Prager (ORCID: https://orcid.org/0000-0002-7854-7781)
- Dora Niedersuess‐Beke (ORCID: https://orcid.org/0000-0003-0544-5773)
- Armin Gerger (ORCID: https://orcid.org/0000-0002-3888-5401)
- Susanne Klein‐Scory (ORCID: https://orcid.org/0000-0003-1930-3354)
- Holger F. Rumpold (ORCID: https://orcid.org/0000-0002-4118-0111)
- Ralf‐Dieter Hofheinz (ORCID: https://orcid.org/0000-0001-5972-8504)
- Dominik Paul Modest (ORCID: https://orcid.org/0000-0002-6853-0599)
- Thomas Winder (ORCID: https://orcid.org/0000-0002-4216-2994)
- Swantje Held (ORCID: https://orcid.org/0000-0002-1344-9056)
- Jörg Kumbrink (ORCID: https://orcid.org/0000-0003-4633-4105)
- Kathrin Heinrich (ORCID: https://orcid.org/0000-0003-3580-2313)
- Florian Kaiser (ORCID: https://orcid.org/0000-0002-5844-1779)
- Stefan Angermeier
- Wolff Schmiegel (ORCID: https://orcid.org/0000-0002-1783-9764)
- Ludwig Fischer von Weikersthal (ORCID: https://orcid.org/0000-0002-9128-0807)
- Jörg Trojan (ORCID: https://orcid.org/0000-0001-9414-378X)
- Leopold Öhler
Institutions
- Goethe University Frankfurt (DE)
- Medical University of Graz (AT)
- University of Applied Sciences Landshut (DE)
- LMU Klinikum (DE)
- München Klinik Bogenhausen (DE)
- Fachhochschule Wiener Neustadt (AT)
- Humboldt-Universität zu Berlin (DE)
- Landeskrankenhaus Feldkirch (AT)
- Wilhelminen Hospital (AT)
- Ravensburg University of Cooperative Education (DE)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Agaplesion Bethesda Krankenhaus (DE)
- ClinAssess (Germany) (DE)
- Klinikum Ludwigsburg (DE)
- Evangelisches Krankenhaus Hamm (DE)
- Klinikum St. Marien Amberg (DE)
- Klinikum Fulda (DE)
- Freie Universität Berlin (DE)
- Medical University of Vienna (AT)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1200/jco.24.01174
- Citations
- 13
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.59