Decoding Obsessive-Compulsive Disorder: The Regional Vulnerability Index and Its Association With Clinical Symptoms

The current results suggest that the RVI may represent an individual characteristic that reflects the degree of correspondence between individual patterns of structural alterations and disease-characteristic patterns of structural alterations. However, our findings also indicate that relatively large effect sizes in the meta-analytic ground truth are a prerequisite for obtaining a meaningful RVI parameter that can also be related to clinical severity. Therefore, the current findings require further validation through additional research to confirm the RVI's robustness and determine its predictive value.