Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis
In summary, utilizing multiomics analyses, we have revealed chromatin accessibility maps and illuminated the intricate molecular mechanisms that underlie cellular heterogeneity during ESCC metastasis, offering valuable insights to further advance research on tumor progression and deterioration.
Authors
- Dianhao Guo (ORCID: https://orcid.org/0000-0002-4102-2295)
- Yawen Sun (ORCID: https://orcid.org/0000-0002-0811-8105)
- Juan Lei (ORCID: https://orcid.org/0000-0002-4324-7500)
- Shuai Liu (ORCID: https://orcid.org/0009-0005-7815-0724)
- Miao Zhang (ORCID: https://orcid.org/0000-0002-7546-7129)
- Qing Li (ORCID: https://orcid.org/0000-0003-3087-4692)
- Yongjie Wang (ORCID: https://orcid.org/0000-0002-0306-3088)
- Jun Chen (ORCID: https://orcid.org/0000-0002-2362-5359)
- Ruitang Xu
- Yang Jia (ORCID: https://orcid.org/0000-0003-4018-5460)
- Jiao Guo (ORCID: https://orcid.org/0000-0002-0050-5055)
- Wenwen Xu (ORCID: https://orcid.org/0000-0003-2756-3498)
- Kaiwen Sheng
- Haoqiang Sun
Institutions
- Shandong Tumor Hospital (CN)
- Shandong Provincial Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12967-025-06154-6
- Citations
- 4
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Taishan Scholar Foundation of Shandong Province
- National College Students Innovation and Entrepreneurship Training Program