Detection of viral antigen and inflammatory mediators in fatal pediatric dengue: a study on lung immunopathogenesis
The results confirm that vascular dysfunctions such as hemorrhage, vascular congestion and edema associated with a mononuclear infiltrate were observed in all three cases. In addition, the presence of viral replication and increased expression of inflammatory markers were also observed. Such findings contribute to the study and description of dengue, especially its effects on lung tissue.
Authors
- Rodrigo Basílio-de-Oliveira
- Gabriela Oliveira (ORCID: https://orcid.org/0000-0002-9008-6201)
- Fernando Colonna Rosman (ORCID: https://orcid.org/0000-0003-4801-4391)
- Natália Gedeão Salomão
- Felipe de Andrade Vieira Alves
- Ronaldo Mohana‐Borges (ORCID: https://orcid.org/0000-0002-1796-475X)
- Jemima Fuentes Ribeiro da Silva (ORCID: https://orcid.org/0000-0001-7867-3131)
- Carlos Alberto Basílio‐de‐Oliveira
- Leandro Junqueira Moragas
- Marciano Viana Paes (ORCID: https://orcid.org/0000-0002-2266-2801)
- Laíza Vianna Arruda (ORCID: https://orcid.org/0009-0001-0074-4291)
- Lucca de Lima Siqueira Oliveira
- Kíssila Rabelo (ORCID: https://orcid.org/0000-0001-7579-7788)
- Caio Gonçalves Azevedo
- Jorge José de Carvalho (ORCID: https://orcid.org/0000-0002-9426-6381)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Hospital Geral de Bonsucesso (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1487284
- Citations
- 2
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Universidade do Estado do Rio de Janeiro