Longitudinal Cognitive Changes in Cerebral Small Vessel Disease
WMH regression was associated with preserved global cognition and improved executive function, compared with stable WMH, while WMH progression was associated with global cognitive decline. Cognitive benefits of WMH regression suggest that WMH-affected tissue can recover, may explain variance in cognitive outcomes, offer an important intervention target, and should be assessed in other populations and longer follow-up times.
Authors
- Susana Muñoz Maniega (ORCID: https://orcid.org/0000-0001-5185-6384)
- Joanna Marguerite Wardlaw (ORCID: https://orcid.org/0000-0002-9812-6642)
- Angela C.C. Jochems (ORCID: https://orcid.org/0000-0001-7392-3066)
- Fergus Doubal (ORCID: https://orcid.org/0000-0002-2769-3148)
- Maria del Carmen Valdés Hernández (ORCID: https://orcid.org/0000-0003-2771-6546)
- Donna McIntyre
- Michael J. Thrippleton (ORCID: https://orcid.org/0000-0001-7858-9917)
- Úna Clancy (ORCID: https://orcid.org/0000-0002-8062-7537)
- Eleni Sakka (ORCID: https://orcid.org/0000-0002-7082-1168)
- Mark E. Bastin (ORCID: https://orcid.org/0000-0002-0490-0845)
- Daniela Jaime García (ORCID: https://orcid.org/0000-0002-9457-9855)
- Francesca M. Chappell (ORCID: https://orcid.org/0000-0002-7742-1757)
- Carmen Arteaga (ORCID: https://orcid.org/0000-0003-2424-7123)
- Gayle Barclay (ORCID: https://orcid.org/0009-0001-2417-2750)
- Ellen V. Backhouse (ORCID: https://orcid.org/0000-0001-5083-9945)
- Olivia KL Hamilton (ORCID: https://orcid.org/0000-0002-5874-0058)
- Stewart Wiseman (ORCID: https://orcid.org/0000-0001-6739-5797)
- Michael Stringer (ORCID: https://orcid.org/0000-0002-3811-4439)
- Charlotte Jardine (ORCID: https://orcid.org/0009-0001-3732-4135)
- Iona Hamilton (ORCID: https://orcid.org/0009-0005-1308-3380)
Institutions
- Edinburgh Royal Infirmary (GB)
- MRC/CSO Social and Public Health Sciences Unit (GB)
- UK Dementia Research Institute (GB)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Neurology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1212/wnl.0000000000213323
- Citations
- 18
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 25.01
Funders
- Medical Research Council
- Biotechnology and Biological Sciences Research Council