Asymmetric Total Synthesis of Janthinoid A
The asymmetric total synthesis of janthinoid A has been accomplished for the first time in 14 steps without using a protecting group. The <i>trans</i>-decalin subunit and the rigid oxabicyclo[3.2.1]octane motif were constructed via an epoxide-initiated cationic π-cyclization reaction and a Fe(ClO<sub>4</sub>)<sub>3</sub>-mediated oxidative cascade cyclization reaction, respectively.
Authors
- Zuwei Song (ORCID: https://orcid.org/0009-0009-7524-4898)
- Zihao Zhou (ORCID: https://orcid.org/0000-0002-3999-3658)
- Zhen Jun Yang (ORCID: https://orcid.org/0000-0001-8036-934X)
- Yuanhe Li (ORCID: https://orcid.org/0000-0003-2128-5634)
- Fu Tang (ORCID: https://orcid.org/0000-0001-5633-7305)
- Zhongchao Zhang (ORCID: https://orcid.org/0000-0001-5017-5691)
- Jiajun Chen (ORCID: https://orcid.org/0000-0003-4489-1717)
Institutions
- Peking University (CN)
- Shenzhen Bay Laboratory (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Peking University Shenzhen Hospital (CN)
- State Key Laboratory of Chemical Engineering (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1021/jacs.4c17480
- Citations
- 9
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 10.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Shenzhen-Hong Kong Institute of Brain Science
- Shenzhen Bay Laboratory