Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer’s Disease
Our results show an upregulation of nine genes involved in NF-κB-mediated inflammation and redox metabolism in the blood of patients with mild AD with severe OSA. Therefore, severe OSA may worsen the inflammation and oxidative damage that are already altered in patients with AD.
Authors
- Leila Romero (ORCID: https://orcid.org/0000-0002-9352-1416)
- Olga Mínguez
- Montserrat Pujol Sabaté
- Elena Milanesi (ORCID: https://orcid.org/0000-0003-2753-3395)
- Gina Manda (ORCID: https://orcid.org/0000-0002-9706-1883)
- Farida Dakterzada (ORCID: https://orcid.org/0000-0001-9720-7160)
- Raquel Huerto
- Gerard Piñol‐Ripoll (ORCID: https://orcid.org/0000-0002-4495-2113)
- Ferrán Barbé (ORCID: https://orcid.org/0000-0002-2340-8928)
- Maria Dobre (ORCID: https://orcid.org/0000-0002-1376-4021)
- Antonio Cuadrado
- Anna Carnes (ORCID: https://orcid.org/0000-0003-2211-380X)
- Adriano Targa (ORCID: https://orcid.org/0000-0002-7577-7661)
Institutions
- Universitat de Lleida (ES)
- Carol Davila University of Medicine and Pharmacy (RO)
- Instituto de Salud Carlos III (ES)
- Hospital Universitari Arnau de Vilanova (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Hospital Universitari de Santa Maria (ES)
- Instituto de Investigaciones Biomédicas Sols-Morreale (ES)
- Hospital La Paz Institute for Health Research (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Institutul National Victor Babes (RO)
- Hospital Clínic de Barcelona (ES)
- Instituto de Investigación Biomédica de Lleida (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s475776
- Citations
- 1
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Fundació la Marató de TV3
- Centres de Recerca de Catalunya
- Ministerul Cercetării, Inovării şi Digitalizării
- European Commission
- Generalitat de Catalunya
- Institució Catalana de Recerca i Estudis Avançats
- Instituto de Salud Carlos III
- European Regional Development Fund
- Departament de Salut, Generalitat de Catalunya
- European Social Fund