Malaria exposure remodels the plasma proteome of Ghanaian children
Our findings confirm earlier reports and identify putative signature proteins implicated in immune tolerance to malaria. Further large-scale and more mechanistic studies will be needed to reveal the key components of the identified pathways that could explain naturally acquired immunity to malaria and possibly be exploited to develop novel therapeutics against P. falciparum.
Authors
- Andrea Fossati (ORCID: https://orcid.org/0000-0001-5170-4903)
- Charles Ochieng’ Olwal (ORCID: https://orcid.org/0000-0003-1747-2963)
- Gordon A. Awandare (ORCID: https://orcid.org/0000-0002-8793-3641)
- Nevan J. Krogan (ORCID: https://orcid.org/0000-0003-4902-337X)
- Nancy Nyakoe (ORCID: https://orcid.org/0000-0003-3847-4300)
- Mehdi Bouhaddou (ORCID: https://orcid.org/0000-0002-9526-1427)
- Yaw Bediako (ORCID: https://orcid.org/0000-0001-9786-7564)
- Benjamin J. Polacco (ORCID: https://orcid.org/0000-0003-1570-9234)
- Danielle L. Swaney (ORCID: https://orcid.org/0000-0001-6119-6084)
- Aminu Mohammed (ORCID: https://orcid.org/0000-0001-5592-1083)
- Martin Gordon (ORCID: https://orcid.org/0009-0009-5253-6505)
- Jacqueline M. Fabius
Institutions
- QB3 (US)
- Gladstone Institutes (US)
- University of Ghana (GH)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- African University College of Communications (GH)
- Quantitative BioSciences (US)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s12879-025-10495-4
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Wellcome Trust
- National Institutes of Health