A Case of McCune Albright Syndrome With Rare Extensive Polyostotic Fibrous Dysplasia

McCune-Albright syndrome is characterized by a triad of café au lait macules, polyostotic fibrous dysplasia (FD), and endocrine abnormalities. Bilateral and extensive presentation of FD is rarely reported. We report an interesting case of 24-year-old woman presenting with multiple episodes of slip and fall, sustaining multiple fractures with history of precocious puberty and skin complaints. On evaluation with 99m Tc-MDP bone scan, all the long bones, ribs, pelvic bones, frontal bone, and maxilla showed deformities and increased osteoblastic activity, suggesting extensive polyostotic FD. Thus emphasizing the crucial role of 99m Tc-MDP bone scan in the diagnosis of extensive FD and guides in understanding of the polyostotic involvement.

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Publication Details

Journal
Clinical Nuclear Medicine
Published
2025-02-03
DOI
https://doi.org/10.1097/rlu.0000000000005674
Primary Topic
Bone Tumor Diagnosis and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

A Case of McCune Albright Syndrome With Rare Extensive Polyostotic Fibrous Dysplasia

Harish Goyal, Harinee Ganesan, Vasanth Madivanane, Kabilash Dhayalane et al.
Clinical Nuclear Medicine
Bone Tumor Diagnosis and Treatments
article

A Case of McCune Albright Syndrome With Rare Extensive Polyostotic Fibrous Dysplasia

Harish Goyal, Harinee Ganesan, Vasanth Madivanane, Kabilash Dhayalane, Ragire Sainath
article en

Abstract

McCune-Albright syndrome is characterized by a triad of café au lait macules, polyostotic fibrous dysplasia (FD), and endocrine abnormalities. Bilateral and extensive presentation of FD is rarely reported. We report an interesting case of 24-year-old woman presenting with multiple episodes of slip and fall, sustaining multiple fractures with history of precocious puberty and skin complaints. On evaluation with 99m Tc-MDP bone scan, all the long bones, ribs, pelvic bones, frontal bone, and maxilla showed deformities and increased osteoblastic activity, suggesting extensive polyostotic FD. Thus emphasizing the crucial role of 99m Tc-MDP bone scan in the diagnosis of extensive FD and guides in understanding of the polyostotic involvement.

Clinical Nuclear MedicineVol. 50(7)
Jawaharlal Institute of Post Graduate Medical Education and Research (IN)
Good health and well-being
Openalex Percentile: Top 97%
Bone Tumor Diagnosis and Treatments
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