One-Pot Synthesis of Core–Shell Au@ <i>m</i> SiO <sub>2</sub> Nanoparticles for Photothermal Applications
Gold-mesoporous silica (Au@mSiO2) core–shell nanoparticles (NPs) hold great promise for application in nanomedicine as they enable the photostimulated release of guest molecules located within their pores. In this study, we investigated the mechanism of a productive one-pot protocol for the preparation of core–shell Au@mSiO2 NPs. The formation of gold NPs quickly followed by the formation of a silica shell eliminates the need to isolate and strongly protect the gold cores. A thorough mechanistic analysis provides insights into the relative kinetics of gold and silica formation, which can be fine-tuned to obtain Au@mSiO2 smaller than 100 nm. The photothermal properties of such Au@mSiO2 were characterized and modeled. Under the experimental conditions typically used for cargo release experiments, the model predicts a temperature increase for a single particle of less than 1 × 10–4 °C, demonstrating that the release is due to the collective heating of the medium by a myriad of NPs, rather than by the temperature elevation of individual NPs under irradiation. Overall, the studies developed here will enable better design and preparation of Au@mSiO2 particles for diverse photothermal applications.
Authors
- Sara A. Bilmes (ORCID: https://orcid.org/0000-0001-7753-229X)
- Philippe Trens (ORCID: https://orcid.org/0000-0001-9162-8263)
- Andrea Montero-Oleas (ORCID: https://orcid.org/0000-0002-4659-775X)
- Xavier Cattoën (ORCID: https://orcid.org/0000-0003-1072-0573)
- María Luz Martínez Ricci (ORCID: https://orcid.org/0000-0003-1281-6915)
- Stéphanie Kodjikian (ORCID: https://orcid.org/0000-0001-7304-3675)
- M. Claudia Marchi (ORCID: https://orcid.org/0000-0002-5347-0212)
- Yoann Roupioz (ORCID: https://orcid.org/0000-0002-1790-8141)
- Guillermo P. Ortiz (ORCID: https://orcid.org/0000-0002-9240-3338)
Institutions
- Institut polytechnique de Grenoble (FR)
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Université de Montpellier (FR)
- Universidad de Buenos Aires (AR)
- National University of the Northeast (AR)
- Instituto de Física La Plata (AR)
- Institut Charles Gerhardt Montpellier (FR)
- Institut Néel (FR)
- Instituto de Física de Buenos Aires (AR)
- Institut des langues et cultures d'Europe, Amérique, Afrique, Asie et Australie (FR)
- Fundación Ciencias Exactas y Naturales (AR)
- Universidad San Francisco de Quito (EC)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- ACS Applied Nano Materials
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1021/acsanm.4c07241
- Citations
- 4
- Primary Topic
- Catalytic Processes in Materials Science
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- Agence Nationale de la Recherche
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires
- Secretaría General de Ciencia y Técnica, Universidad Nacional del Nordeste
- Fondo para la Investigación Científica y Tecnológica