Iron chelation by oral deferoxamine treatment decreased brain iron and iron signaling proteins
WT mice respond to DFO with decreased AβPP, amyloid processing enzymes, and antioxidant repair. Potential DFO treatment for early-stage AD by DFO should consider the benefits of lowered AβPP and secretase enzymes.
Authors
- Peggy A. O’Day (ORCID: https://orcid.org/0000-0002-8698-5159)
- Russell E. Jacobs (ORCID: https://orcid.org/0000-0002-1382-8486)
- Berislav V. Zloković (ORCID: https://orcid.org/0000-0002-6802-8232)
- Caleb E. Finch (ORCID: https://orcid.org/0000-0002-7617-3958)
- Max A. Thorwald
- Naomi S. Sta Maria (ORCID: https://orcid.org/0000-0001-9710-2908)
- Ararat Chakhoyan (ORCID: https://orcid.org/0000-0001-9447-495X)
Institutions
- University of Southern California (US)
- University of California, Merced (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1177/13872877241313031
- Citations
- 8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- Cure Alzheimer's Fund