Analysis of protein interaction network in obesity linked with periodontitis

The clinical link between obesity and periodontitis by investigating the potential interaction among proteins is of interest. A protein-protein interaction (PPI) network analysis using STRING was conducted on novel proteins identified from saliva samples through quantitative proteomics and mass spectrometry. Twenty proteins were involved in molecular process, cellular components and biological functions focusing on proteins with variants closely associated with obesity and periodontitis. Analysis revealed that PPI network exhibited a high degree of interactions, indicating a biological connection with a significant p value 4.8*105. These PPIs discuss the interplay between obesity and periodontitis, require further experimental validation, unravel new clues for downstream studies and propose biological mechanisms through which these two conditions may interact.