Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy
In conclusion, the findings in this study suggest that intra-articular injection of AAV vectors encoding sPD-L1 results in greater therapeutic benefit on arthritis, and systemic AAV/sPD-L1 is able to block the development of inflammatory arthritis with inhibition of the systemic immune response, underlining the potential of gene therapy with systemic delivery of shPD-L1 via AAV vectors in RA.
Authors
- Chengwen Li (ORCID: https://orcid.org/0000-0003-4397-4561)
- Susi Feng
- Panli Zhang (ORCID: https://orcid.org/0000-0001-8691-8514)
- Adalberto Luiz Rosa (ORCID: https://orcid.org/0000-0002-6495-2778)
- Richard F. Loeser (ORCID: https://orcid.org/0000-0003-2832-6144)
- Eveline Y. Wu (ORCID: https://orcid.org/0000-0002-6394-6843)
- Junjiang Sun (ORCID: https://orcid.org/0000-0002-7408-0731)
- Wenjun Li (ORCID: https://orcid.org/0009-0006-8607-2268)
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1527858
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14