Reduced GIRK expression in midbrain dopamine neurons during prolonged abstinence from fentanyl self-administration
These findings suggest that PAMs like KK-92A are a potential therapeutic strategy for opioid use disorder and their effect is likely due to rectifying GABA<sub>B</sub>-R mediated inhibition of midbrain DA neurons, which is reduced after opioid SA due to reduced GIRK<sub>2/3</sub> expression.
Authors
- Andrew Belilos (ORCID: https://orcid.org/0000-0002-6059-2146)
- Samuel J. Dienel (ORCID: https://orcid.org/0000-0002-1751-5460)
- Narges Pachenari (ORCID: https://orcid.org/0000-0001-5528-6008)
- Khaled Moussawi (ORCID: https://orcid.org/0000-0001-6378-0428)
- Amy L. Channell
Institutions
- National Institute on Drug Abuse (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1007/s00213-025-06747-5
- Citations
- 3
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.73