Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins
Our study uncovers a novel mechanism by which cancer cells evade immune-mediated ferroptosis through Fabp7 upregulation. This protein reprograms lipid metabolism and disrupts circadian regulation in immune cells, promoting tumor survival and resistance to immunotherapy. Targeting Fabp7 could enhance immunotherapy effectiveness by re-sensitizing resistant tumors to ferroptosis.
Authors
- Cyrielle Billon
- Thomas P. Burris (ORCID: https://orcid.org/0000-0003-2922-4449)
- Iqbal Mahmud (ORCID: https://orcid.org/0000-0001-7729-8122)
- Nahum Puebla‐Osorio (ORCID: https://orcid.org/0000-0001-6498-5230)
- Shonik Ganjoo (ORCID: https://orcid.org/0009-0008-9800-2165)
- Yun Hu (ORCID: https://orcid.org/0000-0001-5597-9234)
- Vinay K. Puduvalli (ORCID: https://orcid.org/0000-0001-8396-9500)
- Claudia S. Kettlun Leyton (ORCID: https://orcid.org/0000-0001-9158-6964)
- Michael A. Davies (ORCID: https://orcid.org/0000-0002-0977-0912)
- Efrosini Tsouko
- Ailing Huang
- Jian Hu (ORCID: https://orcid.org/0000-0001-6657-9826)
- Philip L. Lorenzi (ORCID: https://orcid.org/0000-0003-0385-7774)
- Fatemeh Masrorpour (ORCID: https://orcid.org/0000-0001-5107-3275)
- Boyi Gan (ORCID: https://orcid.org/0000-0001-8884-6040)
- Hampartsoum B. Barsoumian (ORCID: https://orcid.org/0000-0002-8209-6119)
- Kevin Lin (ORCID: https://orcid.org/0000-0002-1236-9847)
- James W. Welsh (ORCID: https://orcid.org/0000-0002-2255-8502)
- Thomas S. Riad
- Lisa K. Duong
- Carola Leuschner (ORCID: https://orcid.org/0000-0003-2219-2931)
- Tiffany A. Voss
- Bo Wei (ORCID: https://orcid.org/0000-0002-1058-5888)
- Yue Lu (ORCID: https://orcid.org/0000-0002-5479-9095)
- Qi Wang (ORCID: https://orcid.org/0000-0002-1588-9047)
- Jing Wang (ORCID: https://orcid.org/0000-0002-5398-0802)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-9941-1568)
- Hong Jiang (ORCID: https://orcid.org/0000-0002-1893-0121)
- WaiKin Chan
- Maria Angelica Freitas-Cortez
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- University of Health Sciences and Pharmacy (US)
- University of Florida (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1186/s12943-024-02198-2
- Citations
- 26
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 39.48
Funders
- U.S. Department of Defense
- Bristol-Myers Squibb
- Cancer Prevention and Research Institute of Texas
- Melanoma Research Alliance
- Gilead Sciences
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Varian Medical Systems
- AIM at Melanoma
- Dan L. Duncan Cancer Center, Baylor College of Medicine
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Cancer Institute