Simple steps to achieve harmonisation and standardisation of dried blood spot phenylalanine measurements and facilitate consistent management of patients with phenylketonuria
This study demonstrates a simple approach to harmonising and standardising DBS Phe measurements, traceable to value assigned materials. Combined with the introduction of DBS-MCs to ensure specimen quality, clinical laboratories can achieve comparability of patient results over time.
Authors
- Emily Whyte (ORCID: https://orcid.org/0000-0001-8618-4178)
- S. Hogg (ORCID: https://orcid.org/0000-0002-3642-5604)
- Chris Hopley (ORCID: https://orcid.org/0000-0001-6212-8227)
- Nana Ghansah
- Stuart J. Moat (ORCID: https://orcid.org/0000-0002-3592-2254)
- Alistair Horman
- Nathan Cantley
- Zoe Barclay
- Rachel S. Carling (ORCID: https://orcid.org/0000-0003-1988-3088)
- Simon Cowen (ORCID: https://orcid.org/0000-0002-3305-369X)
- Chloe Deaves
Institutions
- North Bristol NHS Trust (GB)
- King's College London (GB)
- Great Ormond Street Hospital (GB)
- University Hospital of Wales (GB)
- Southmead Hospital (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- King's College School (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Middlesex University London (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1515/cclm-2024-1367
- Citations
- 4
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.27
Funders
- Goddard Space Flight Center