Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses
The pipeline not only serves as a valuable resource for automating ecDNA detection in metaphase FISH images but also highlights the role of ecDNA in facilitating swift and reversible adaptation to epigenetic remodeling agents such as JQ1.
Authors
- Elizabeth Brunk (ORCID: https://orcid.org/0000-0001-8578-8658)
- Christina Ford
- Oliver Cope
- Jingting Chen (ORCID: https://orcid.org/0000-0001-9806-9054)
- Kohen Goble
- David Cheng (ORCID: https://orcid.org/0000-0003-4854-8190)
- Yue Wang (ORCID: https://orcid.org/0009-0009-4348-4432)
- Kriti Shukla (ORCID: https://orcid.org/0000-0001-9201-1417)
- J H Fessler
- William C. Dennis
- Aarav Mehta
- Nithya Gurumurthy
- Damien Guilbaud
- William Nenad (ORCID: https://orcid.org/0009-0003-2648-0671)
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3389/fphar.2024.1516621
- Citations
- 5
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- University of North Carolina at Chapel Hill
- National Institute of General Medical Sciences