Assessment of prognosis and responsiveness to immunotherapy in colorectal cancer patients based on the level of immune cell infiltration
This study revealed a significant correlation between high levels of immune infiltration and unfavorable prognosis in patients with colon cancer. Furthermore, an accurate prognostic risk prediction model based on the co-expression of relevant genes by immune cells was developed, enabling precise prediction of survival of colon cancer patients. These findings offer valuable insights for accurate prognostication and comprehensive management of individuals diagnosed with colon cancer.
Authors
- Qionghui Zhong (ORCID: https://orcid.org/0000-0003-1934-5562)
- Lei Ming Guo (ORCID: https://orcid.org/0000-0002-6072-2377)
- Yixin Jiang (ORCID: https://orcid.org/0000-0002-0883-5999)
- Xiaozhong Wang (ORCID: https://orcid.org/0000-0001-8152-8971)
- Jingyan Zhang (ORCID: https://orcid.org/0000-0001-6979-0969)
- Bingying Lin
- Jinting Cheng
- Yanmei Xu (ORCID: https://orcid.org/0000-0003-3610-2968)
- Zijun Gao
- Kaili Liao
- Tingyi Qian
- Bing Sun (ORCID: https://orcid.org/0009-0000-1856-2704)
- Yihui Qian
- Minqi Zhu (ORCID: https://orcid.org/0000-0001-8701-3477)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1514238
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China