Ketamine effects on resting state functional brain connectivity in major depressive disorder patients: a hypothesis-driven analysis based on a network model of depression
This study demonstrates that ketamine specifically affects depression-related circuitry. Analyzing functional connectivity based on a neurocircuitry model of a specific CNS disease and drug action may be an effective approach that could result in a more targeted analysis in future pharmaco-fMRI studies in CNS drug development.
Authors
- Kantaro Nishigori
- Nic J. van der Wee
- Nadieh Drenth (ORCID: https://orcid.org/0000-0002-8793-6201)
- Kasper Recourt (ORCID: https://orcid.org/0000-0001-9282-9307)
- Jeroen van der Grond (ORCID: https://orcid.org/0000-0002-0185-3158)
- Joop van Gerven (ORCID: https://orcid.org/0000-0002-1444-7415)
- Gabriël E. Jacobs (ORCID: https://orcid.org/0000-0002-5140-9450)
Institutions
- Leiden University Medical Center (NL)
- Sumitomo Dainippon Pharma (Japan) (JP)
- Centre for Human Drug Research (NL)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3389/fnins.2025.1531375
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00