Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling
RES potentiates ULBP2-mediated immune eradication of BC cells by NK cells through the downregulation of miR-17-5p and concurrent activation of the MINK1/JNK/c-Jun cascade. This finding identifies RES as a potentially effective therapeutic agent for inhibiting BC progression and optimizing NK cell-based cancer immunotherapy.
Authors
- Chunyan Jiang (ORCID: https://orcid.org/0000-0001-8757-6229)
- Jia-Lin Yan
- Jie Li (ORCID: https://orcid.org/0000-0002-4635-8994)
- Ling-Bo Qian (ORCID: https://orcid.org/0000-0003-4517-9908)
- Jie Pan
- Bisha Ding
Institutions
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1515605
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Department of Education of Zhejiang Province
- Natural Science Foundation of Zhejiang Province