Hypoxia-driven mobilization of altruistic cancer stem cells in platinum-treated head and neck cancer
This study reveals that HNSCC patients undergoing platinum therapy can harbor TSD+ CTCs exhibiting an altruistic phenotype and a hypoxic signature. Additionally, the pre-clinical study provides a novel non-genetic mechanism of therapy resistance-the altruistic tumor self-defense. The tumor microenvironment, through the emergence of TSD+ CSCs, appears to act collectively to defend the tumor self-identity by hijacking an altruistic stem cell niche defense mechanism.
Authors
- Lekhika Pathak
- Sorra Sandhya (ORCID: https://orcid.org/0009-0009-8643-6828)
- Bikul Das (ORCID: https://orcid.org/0000-0002-6016-335X)
- Sanjukta Patra (ORCID: https://orcid.org/0000-0002-8624-3323)
- Bidisha Pal
- Jyotirmoy Phukan
- Joyeeta Talukdar (ORCID: https://orcid.org/0000-0002-4922-2283)
- Wale Tasabehji
- Hong Li (ORCID: https://orcid.org/0000-0003-0280-4697)
- Partha Jyoti Saikia
- Anjan Bhuyan
Institutions
- Indian Institute of Technology Guwahati (IN)
- University of Massachusetts Lowell (US)
- Gauhati Medical College and Hospital (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3389/fimmu.2024.1336882
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09