Multi-omics approaches reveal the therapeutic mechanism of Naoxintong capsule against ischemic stroke
Our study indicates that NXT reduces the abundance of Parasutterella_massiliensis and Ihubacter_excrementihominis, while increasing the levels of serine, lysine, and proline. These changes are significantly associated with neuroinflammation. Furthermore, NXT alleviates IS-induced neuroinflammation by inhibiting the TLR4/NF-κB pathway. Importantly, our study provides novel insights into the mechanisms underlying NXT's therapeutic effects on IS.
Authors
- Shihuan Tang (ORCID: https://orcid.org/0000-0003-0589-4499)
- Jing Xu (ORCID: https://orcid.org/0000-0002-8926-0890)
- Mengli Chang (ORCID: https://orcid.org/0000-0003-2546-308X)
- Yuxin Lei
- Jing Zhang (ORCID: https://orcid.org/0009-0005-4343-5949)
- Yu Li (ORCID: https://orcid.org/0000-0002-7670-3998)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1016/j.jep.2025.119435
- Citations
- 5
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 7.79