Frequency of Polymorphisms of rs2274907 of Omentin Gene and rs9770242 of Visfatin Gene in Non-Alcoholic Fatty Liver Disease in an Iranian Population

Introduction: Non-alcoholic fatty liver disease is the most common chronic disease, frequently occurring in various instances; if left undiagnosed and untreated, it will progress to cirrhosis and, in some cases, result in death. This disease is related to obesity, high blood pressure, metabolic syndrome and diseases and treatment. The Omentin gene consists of 8 exons and 7 introns, producing a protein made up of 313 amino acids. Visfatin is another adipokine. The Visfatin gene is located on the big arm of chromosome 7. The purpose of this study was to investigate the relationship between rs2274907 omentin and rs9770242 visfatin polymorphisms with non-alcoholic fatty liver disease in an Iranian population. Methods: This study was carried out through a case-control study involving 70 patients with non-alcoholic fatty liver disease and 70 healthy individuals. The level of fasting blood sugar, triglyceride, cholesterol, HDL, and LDL was measured by standard methods; the amount of Omentin was measured with an ELISA kit. Genotype was determined by PCR-RFLP method. The data were analyzed by SPSS software version 16. Results: The two investigated groups showed a significant difference in terms of age, BMI, LDL, HDL (P<0.05). The levels of triglycerides, omentin and average body mass profile were higher in the individuals with NAFLD; the level of HDL-C was lower than healthy individuals. Omentin had a significant relationship with the body mass level of LDL-C and HDL-C. Conclusion: The current research demonstrated a notable connection between omentin and non-alcoholic fatty liver disease. This polymorphism of rs2274907 in the omentin gene has a significant relationship with non-alcoholic fatty liver disease.