Brain Iron Alteration in Pediatric Tourette Syndrome: A Quantitative Susceptibility Mapping Study
Our findings suggest that disturbed brain iron homeostasis in specific regions is associated with pediatric TS. These results reinforce the importance of the cortico-striato-thalamo-cortical circuits in TS pathogenesis and highlight the potential role of iron dysregulation. Furthermore, our study demonstrates that QSM could serve as a valuable auxiliary biomarker for diagnosing and potentially monitoring pediatric TS.
Authors
- Yanglei Cheng
- Zhiyun Yang (ORCID: https://orcid.org/0000-0002-6139-9049)
- Y B Li (ORCID: https://orcid.org/0009-0003-6395-678X)
- Zhiping Ruan (ORCID: https://orcid.org/0000-0001-9467-7466)
- Wei Cui (ORCID: https://orcid.org/0000-0002-2480-8667)
- Long Qian (ORCID: https://orcid.org/0000-0002-9707-1096)
- Yujian Liang (ORCID: https://orcid.org/0000-0002-3812-9120)
- Huaqiong Qiu
- Shu Su (ORCID: https://orcid.org/0000-0001-8704-9752)
- Liping Lin (ORCID: https://orcid.org/0000-0003-3641-8102)
- Wen Tang
- Chengfen Deng
Institutions
- Sun Yat-sen University (CN)
- Peking University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/ene.70054
- Citations
- 4
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.23
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province