The Effect of Aerobic Training along with Resveratrol Supplementation on Some Inflammatory Index Levels in the Spinal Cord Tissue of Rats after Spinal Cord Injury

Introduction: Spinal cord injury (SCI) is associated with increased inflammation in the spinal cord tissue of the injured individual. The purpose of present study was to examined how aerobic training along with resveratrol supplementation influenced on spinal IL-1β and IL-10 levels in rats suffering from SCI. Methods: Forty-five male Wistar rats, eight weeks old, were divided into five groups: healthy, control, resveratrol, aerobic training and resveratrol+ training. Spinal cord injury was caused by dropping a ten-gram weight from a height of 25 mm on the spinal cord in the T10 segment. Resveratrol supplement with a dose of 10 mg/kg was injected intraperitoneally and daily. The aerobic training was conducted utilizing the weight support system over a period of 4 weeks, with each session lasting 58 minutes and an intensity of 20 m/min. One-way ANOVA and the LSD post hoc test were applied at a significance level of p<0.05. Results: The level of spinal IL-1β in the control group was significantly higher than healthy group (p=0.005). The level of this index was significantly lower in resveratrol (p=0.011), aerobic training (p=0.002), and resveratrol+training (p=0.016) groups than control group. The level of spinal IL-10 in control group was significantly lower than healthy group (p=0.011). The index in aerobic training and resveratrol+ training groups exhibited an elevation relative to the control group, although this difference was not statistically significant (p<0.05). Conclusion: Aerobic training along with resveratrol supplementation can have positive effects on the inflammation of the injured area due to SCI and possibly prevent secondary injuries and side effects of SCI in the injured area of the spinal cord of these subjects.