ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway
ELA enhances BMSCs migration and homing to injured cardiomyocytes by activating the APJ receptor, promoting ERK1/2 phosphorylation, downregulating miR-299a-5p, and upregulating Exo70, providing a potential therapeutic strategy for improving stem cell-based cardiac repair.
Authors
- Jiaying Fu (ORCID: https://orcid.org/0000-0003-2425-7866)
- Shuangmei Li
- Yajie Guo (ORCID: https://orcid.org/0000-0001-5473-207X)
- Haidong Wu (ORCID: https://orcid.org/0000-0003-1244-2423)
- Huibao Long
- Xu‐Xiang Chen
- Xiaojing Li (ORCID: https://orcid.org/0000-0002-3958-0167)
- Tong Wang (ORCID: https://orcid.org/0000-0001-7697-5494)
- Shujun Yang (ORCID: https://orcid.org/0009-0009-3963-264X)
- Hao Wu (ORCID: https://orcid.org/0009-0000-1496-5290)
- Jingyu Hou (ORCID: https://orcid.org/0000-0001-7000-1808)
- Changqing Zhou (ORCID: https://orcid.org/0000-0002-7269-6380)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3389/fphar.2025.1541869
- Citations
- 3
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Shenzhen Fundamental Research Program
- Fundamental Research Funds for the Central Universities