Electroacupuncture induces analgesia by regulating spinal synaptic plasticity via the AMPA/NMDA receptor in a model of cervical spondylotic radiculopathy: secondary analysis of an experimental study in rats
Evidence of EA analgesia (higher PPT and MWT scores) was seen after 5 days of EA, while positive effects on motor function required 7 days of treatment. The underlying mechanism may be related to inhibition of AMPAR and NMDAR expression, regulation of the concentration of related neurotransmitters and improvement of spinal cord synaptic plasticity. This study establishes a preliminary theoretical foundation for the use of EA in the clinical treatment of CSR.
Authors
- Pu Yang (ORCID: https://orcid.org/0000-0002-6231-4721)
- Haiyan Chen (ORCID: https://orcid.org/0000-0001-5012-6865)
- Xi Zhang (ORCID: https://orcid.org/0000-0001-6495-2586)
- Tian Wang (ORCID: https://orcid.org/0009-0000-9316-1177)
- Sheng-Yong Su
Institutions
- Guangxi University of Chinese Medicine (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Publication Details
- Journal
- Acupuncture in Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1177/09645284251314189
- Citations
- 4
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- National Natural Science Foundation of China