Fusarolides A–C, Three Pyran-Macrolide Hybrids from a Marine Derived Fungal <i>Fusarium verticillioide</i> G102 as <i>Asialoglycoprotein receptor</i> 1 Inhibitor and Phytopathogenic Fungicides
Three undescribed 20-membered macrolides, fusarolides A-C (<b>1</b>-<b>3</b>), with relatively rare pyran-macrolide structures and complex chiral centers, were isolated from a marine derived fungal <i>Fusarium verticillioide</i> G102. Their chemical structures and stereoconfigurations were well elaborated. Compound <b>1</b> promoted cholesterol efflux from Huh-7 cells in a concentration-dependent manner by inhibiting <i>Asialoglycoprotein receptor</i> 1 (ASGR1), which was identified as a new therapeutic target in hypercholesterolemia in liver. Besides, compounds <b>1</b>-<b>3</b> exhibited obvious anti-phytopathogenic fungal activities.
Authors
- Kemin Dong
- Xiao-Ping Peng (ORCID: https://orcid.org/0000-0003-4611-8955)
- Hong‐Xiang Lou (ORCID: https://orcid.org/0000-0003-3300-1811)
- Gang Li (ORCID: https://orcid.org/0000-0003-0621-2779)
- Yan Liu (ORCID: https://orcid.org/0000-0002-8607-4363)
- Yuhan Zhang (ORCID: https://orcid.org/0009-0006-0178-9404)
- KeWei Wang (ORCID: https://orcid.org/0000-0001-7023-9998)
- Limei Wang (ORCID: https://orcid.org/0000-0002-0333-5063)
Institutions
- Qingdao University (CN)
- Mission Health (US)
- Shandong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1021/acs.orglett.4c04789
- Citations
- 3
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Key Technology Research and Development Program of Shandong