New Ru(III) 2,6‐Bis(2‐Benzimidazolyl)Pyridine Complexes Bearing P‐Sub‐Benzyl Thiosemicarbazones Schiff Base: Synthesis, Characterization, DNA Binding and Anti‐cancer Activity
The six mononuclear Schiff's base Ru(III) complexes viz., [Ru(BZP)(LA)<sub>2</sub>].2NO<sub>3</sub> (MRA), [Ru(BZP)(LB)<sub>2</sub>].2NO<sub>3</sub> (MRB), [Ru(BZP))(LC)<sub>2</sub>].2NO<sub>3</sub> (MRC), [Ru(BZP))(LD)<sub>2</sub>].2NO<sub>3</sub> (MRD), [Ru(BZP)(LE)<sub>2</sub>].2NO<sub>3</sub> (MRE) and [Ru(BZP)(LF)<sub>2</sub>].2NO<sub>3</sub> (MRF), were synthesized using of (BZP=2,6-bis(2-benzimidazolyl)pyridine and p-sub-benzylthiosemicarbazones (BTS) [(Sub=4-NO<sub>2</sub> (LA), 4-N(CH<sub>3</sub>)<sub>2</sub> (LB), 4-Cl (LC), 4-OCH<sub>3</sub> (LD), 4-OCH<sub>2</sub>Ph (LE), and 4-OH (LF)] as an ancillary ligands. The thiosemicarbazones ligands (LA-LF) were obtained by the condensation of p-substituted benzaldehyde and thiosemicarbazide. These complexes were characterized by elemental analysis, IR, ESR, ESI-MS, electronic absorption spectroscopy. The geometry was optimized by theoretical calculation using DFT and structure reveals that MRA-MRF adopt octahedral geometry. Further, the complexes were examined for anti-cancer against Leukemia cancer cell line K562 and shown significant responses to these cells. Moreover, DNA binding studies were conducted with all complexes MRA-MRF and the binding constant (K<sub>b</sub>) were found i.e., 1.10×10<sup>4</sup>, 1.54×10<sup>4</sup>, 2.87×10<sup>4</sup>, 1.67×10<sup>4</sup>, 1.98×10<sup>4</sup> and 1.59×10<sup>4</sup>, respectively. It was found that DNA binds in intercalation mode which is also validated by the docking studies.
Authors
- Kumud Pandav (ORCID: https://orcid.org/0000-0002-4513-1739)
- Ravindra Kumar Singh (ORCID: https://orcid.org/0000-0003-4772-8181)
- Sudheer Kumar Singh (ORCID: https://orcid.org/0000-0001-7397-4840)
- Farha Arshi (ORCID: https://orcid.org/0000-0002-2891-5697)
- Shahana Bano (ORCID: https://orcid.org/0000-0002-6907-1777)
- R. Chandra (ORCID: https://orcid.org/0000-0003-1677-277X)
- Ashok Kumar Singh (ORCID: https://orcid.org/0000-0002-2539-2229)
- Amarendra Kumar (ORCID: https://orcid.org/0000-0003-0853-9900)
Institutions
- Indian Institute of Technology Roorkee (IN)
- Central Drug Research Institute (IN)
- University of Lucknow (IN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1002/asia.202500059
- Citations
- 2
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 2.09